Melatonin/nanoclay hybrids for skin delivery
نویسندگان
چکیده
Melatonin is a hormone used for treating several disorders. However, its oral administration problematic due to the variable absorption and extensive first-pass metabolism. The topical application of this drug does not present these disadvantages can be therapeutic skin protection purposes. adsorption release melatonin in montmorillonite clay were investigated experimentally theoretically. drug-clay interaction products prepared characterized, showing modified improved melatonin. crystal structure spectroscopic properties melatonin-water-mineral materials studied by molecular modeling, finding that energetically favourable, results consistent with experimental data. Ab initio dynamics simulations metadynamics methodology showed from confined interlayer nanospace liquid bulk water 20 kcal/mol free energy barrier.
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ژورنال
عنوان ژورنال: Applied Clay Science
سال: 2022
ISSN: ['1872-9053', '0169-1317']
DOI: https://doi.org/10.1016/j.clay.2022.106417